Isomerase that catalyzes the conversion of unstable intermediate of prostaglandin E2 H2 (PGH2) into the more stable prostaglandin E2 (PGE2) form (By similarity). May also have transactivation activity toward IFN-gamma (IFNG), possibly via an interaction with CEBPB; however, the relevance of transcription activation activity remains unclear.
Specificity
Natural and recombinant Mouse Prostaglandin E synthase 2
Subcellular Location
Prostaglandin E synthase 2 truncated form Cytoplasm Synthetized as a Golgi membrane-bound protein, which is further cleaved into the predominant soluble truncated form.