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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Inducible T-cell costimulator

SKU : BHE13805596

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15375m
Alternative Names	Activation-inducible lymphocyte immunomediatory molecule ; CD28 and CTLA-4-like protein ; CCLP ; CD28-related protein 1 ; CRP-1 ; CD278 ; Ailim
Categories	Elisa
Function	Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
Specificity	Natural and recombinant Mouse Inducible T-cell costimulator
Subcellular Location	Membrane Single-pass type I membrane protein
Entryname	ICOS_MOUSE
Protein Name	Inducible T-cell costimulator
Sequence	50: MKPYFCRVFV ; FCFLIRLLTG ; EINGSADHRM ; FSFHNGGVQI ; SCKYPETVQQ ; 100: LKMRLFRERE ; VLCELTKTKG ; SGNAVSIKNP ; MLCLYHLSNN ; SVSFFLNNPD ; 150: SSQGSYYFCS ; LSIFDPPPFQ ; ERNLSGGYLH ; IYESQLCCQL ; KLWLPVGCAA ; 200:
Sequence Length	200
String	Q9WVS0
Sub Unit	Homodimer; disulfide-linked.

Uniprot	Q9WVS0
Gene Name	Icos
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:54167
Unigene	Mm.42044

Reference	1. "T-cell co-stimulation through B7RP-1 and ICOS." Yoshinaga S.K., Whoriskey J.S., Khare S.D., Sarmiento U., Guo J., Horan T., Shih G., Zhang M., Coccia M.A., Kohno T., Tafuri-Bladt A., Brankow D., Campbell P., Chang D., Chiu L., Dai T., Duncan G., Elliott G.S., Hui A., McCabe S.M., Scully S., Shahinian A., Shaklee C.L., Van G., Mak T.W., Senaldi G.more... Nature402:827-832(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE;FUNCTION;TISSUE SPECIFICITY tissue: Intestinal epithelium. 2. "Identification and characterization of rat AILIM/ICOS, a novel T-cell costimulatory molecule, related to the CD28/CTLA4 family." Tezuka K., Tsuji T., Hirano D., Tamatani T., Sakamaki K., Kobayashi Y., Kamada M. Biochem. Biophys. Res. Commun.276:335-345(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE;TISSUE SPECIFICITY tissue: Spleen. 3. "Molecular cloning and characterization of murine ICOS and identification of B7h as ICOS ligand." Mages H.W., Hutloff A., Heuck C., Buechner K., Himmelbauer H., Oliveri F., Kroczek R.A. Eur. J. Immunol.30:1040-1047(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];GLYCOSYLATION;SUBUNIT;TISSUE SPECIFICITY strain: BALB/c. tissue: Spleen. 4. "The inducible costimulatory (ICOS) molecule is critical for CD40-mediated antibody class switching." McAdam A.J., Greenwald R.J., Levin M.A., Chernova T., Malenkovich N., Ling V., Freeman G.J., Sharpe A.H. Nature409:102-105(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE;FUNCTION strain: 129/Ola. 5. "CCLP, A novel molecule that regulates T cell activation." Wu D., Giannoni M.A., Kiesecker C.L., Faas S.J., Mickle A.P., Matis L.A., Rother R.P. Submitted (2000-04) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE strain: BALB/c. tissue: Spleen. 6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Mammary gland. 7. "ICOS is essential for effective T-helper-cell responses." Tafuri A., Shahinian A., Bladt F., Yoshinaga S.K., Jordana M., Wakeham A., Boucher L.-M., Bouchard D., Chan V.S., Duncan G., Odermatt B., Ho A., Itie A., Horan T., Whoriskey J.S., Pawson T., Penninger J.M., Ohashi P.S., Mak T.W.more... Nature409:105-109(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION

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