Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Resistant to dipyridamole and dilazep inhibition (anticancer chemotherapeutics drugs).
Specificity
Natural and recombinant Mouse Equilibrative nucleoside transporter 1
Subcellular Location
Basolateral cell membrane Multi-pass membrane protein Apical cell membrane Multi-pass membrane protein