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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse E3 ubiquitin-protein ligase DTX1

SKU : BHE13803168

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2670m
Alternative Names	FXI-T1 ; Protein deltex-1 ; Deltex1 ; RING-type E3 ubiquitin transferase DTX1
Categories	Elisa
Function	Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1. Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
Specificity	Natural and recombinant Mouse E3 ubiquitin-protein ligase DTX1
Subcellular Location	Cytoplasm Nucleus Predominantly cytoplasmic (By similarity). Associates with endocytic vesicles (By similarity). Partially nuclear.
Detection Range	0.156-10ng/mL
Entryname	DTX1_MOUSE
Method Type	Sandwich
Platform	PF02825
Protein Name	E3 ubiquitin-protein ligase DTX1
Sensitivity	0.078ng/mL
Sequence	50: MSRPGQGVMV ; PVNGLGFPPQ ; NVARVVVWEW ; LNEHSRWRPY ; TATVCHHIEN ; 100: VLKEDARGSV ; VLGQVDAQLV ; PYIIDLQSMH ; QFRQDTGTMR ; PVRRNFYDPS ; 150: SAPGKGIVWE ; WENDGGAWTA ; YDMDICITIQ ; NAYEKQHPWL ; DLSSLGFCYL ; 200: IYFNSMSQMN ; RQTRRRRRLR ; RRLDLAYPLT ; VGSIPKSQSW ; PVGASSGQPC ; 250: SCQQCLLVNS ; TRAASNAILA ; SQRRKAPIAP ; AAPPAPPPPP ; PPLPPGGPPG ; 300: ALVVRPSATF ; AGAALWAAPA ; TGPTEPAPPP ; GVPPRSPSAP ; NGAPTPGQNN ; 350: LSRPGPQRST ; SVSARASIPP ; GVPALPVKNL ; NGTGPVHPAL ; AGMTGILLCA ; 400: AGLPVCLTRA ; PKPILHPPPV ; SKSDVKPVPG ; VPGVCRKTKK ; KHLKKSKNPE ; 450: DVVRRYMQKV ; KNPPDEDCTI ; CMERLVTASG ; YEGVLRNKSV ; RPELVGRLGR ; 500: CGHMYHLLCL ; VAMYSNGNKD ; GSLQCPTCKA ; IYGEKTGTQP ; PGKMEFHLIP ; 550: HSLPGFADTQ ; TIRIVYDIPT ; GIQGPEHPNP ; GKKFTARGFP ; RHCYLPNNEK ; 600: GRKVLRLLIT ; AWERRLIFTI ; GTSNTTGESD ; TVVWNEIHHK ; TEFGSNLTGH ; 627: GYPDASYLDN ; VLAELTAQGV ; SEAMAKA
Sequence Length	627
String	Q61010
Sub Unit	Interacts with EP300. Forms a heterodimer with BBAP; the heterodimerization leading to an increase of in vitro ubiquitin ligase activity (By similarity). Homomultimer. May form a heteromultimer with other members of the Deltex family. Interacts with NOTCH1. Interacts with ITCH.

Uniprot	Q61010
Gene Name	Dtx1
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:14357
Unigene	Mm.1645

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SKU	Supplier No.	Size	Your price	Quantity
BHE13803168	E2670m	96T	$776		Add to Cart

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