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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Dysbindin

SKU : BHE13803475

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E14962m
Alternative Names	Biogenesis of lysosome-related organelles complex 1 subunit 8 ; BLOC-1 subunit 8 ; Dysbindin-1 ; Dystrobrevin-binding protein 1 ; Hermansky-Pudlak syndrome 7 protein homolog ; HPS7 protein homolog ; Bloc1s8 ; Sdy
Categories	Elisa
Function	The BLOC-1 complex is required for normal biogenesis of lysosome-related organelles, such as platelet dense granules and melanosomes. Plays a role in intracellular vesicle trafficking. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. May be required for normal dopamine homeostasis in the cerebral cortex, hippocampus, and hypothalamus. Plays a role in the regulation of cell surface exposure of DRD2. Contributes to the regulation of dopamine signaling. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation.
Specificity	Natural and recombinant Mouse Dysbindin
Subcellular Location	Cytoplasm Cytoplasmic vesicle membrane Peripheral membrane protein Cytoplasmic side Cytoplasmic vesicle secretory vesicle synaptic vesicle membrane Peripheral membrane protein Cytoplasmic side Endosome membrane Peripheral membrane protein Cytoplasmic side Melanosome membrane Peripheral membrane protein Cytoplasmic side Cell junction synapse postsynaptic cell membrane postsynaptic density Endoplasmic reticulum Nucleus Detected in neuron cell bodies, axons and dendrites. Detected at synapses, at post-synaptic density, at pre-synaptic vesicle membranes and microtubules. Detected at tubulovesicular elements in the vicinity of the Golgi apparatus and of melanosomes.
Entryname	DTBP1_MOUSE
Method Type	Sandwich
Platform	PF04440
Protein Name	Dysbindin
Sequence	50: MLETLRERLL ; SVQQDFTSGL ; KTLSDKSREA ; KVKGKPRTAP ; RLPKYSAGLE ; 100: LLSRYEDAWA ; ALHRRAKECA ; DAGELVDSEV ; VMLSAHWEKK ; RTSLNELQGQ ; 150: LQQLPALLQD ; LESLMASLAH ; LETSFEEVEN ; HLLHLEDLCG ; QCELERHKQA ; 200: QAQHLESYKK ; SKRKELEAFK ; AELDTEHTQK ; ALEMEHTQQL ; KLKERQKFFE ; 250: EAFQQDMEQY ; LSTGYLQIAE ; RREPMGSMSS ; MEVNVDVLEQ ; MDLMDISDQE ; 300: ALDVFLNSGG ; EDNIVMSPGV ; EMESNPNQNE ; MSLQIPSPSE ; SASQPPASPS ; 350: ACTDLDTADA ; PLIQSDEEEV ; QVDTALVTLH ; TDRKSTPGVS ; DDSDQCDSTQ ; 352: DI
Sequence Length	352
String	Q91WZ8
Sub Unit	Part of the biogenesis of lysosome-related organelles complex 1 (BLOC-1). The BLOC-1 complex is composed of BLOC1S1, BLOC1S2, BLOC1S3, DTNBP1, MUTED, PLDN, CNO/cappuccino and SNAPIN. Interacts with AP3M1 and TRIM32 (By similarity). Interacts with the DNA-dependent protein kinase complex DNA-PK (By similarity). Identified in a complex with the biogenesis of lysosome-related organelles complex 2 (BLOC-2) (By similarity). Binds to DTNA and DTNB but may not be a physiological binding partner (PubMed:16448387 and PubMed:16980328). Interacts with AP3B2. Identified in a complex with the adapter-related protein complex 3 (AP-3). Interacts with RNF151 and CMYA5.

Uniprot	Q91WZ8
Gene Name	Dtnbp1
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:94245
Unigene	Mm.352311

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SKU	Supplier No.	Size	Your price	Quantity
BHE13803475	E14962m	96T	$776		Add to Cart

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