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ELISA Kit for Mouse DNA (cytosine-5)-methyltransferase 1

SKU : BHE13803603

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2102m
Alternative Names	DNA methyltransferase MmuI ; DNA MTase MmuI ; MCMT ; Dnmt ; Met1 ; Uim
Categories	Elisa
Function	Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9.
Specificity	Natural and recombinant Mouse DNA (cytosine-5)-methyltransferase 1
Subcellular Location	Nucleus Cytoplasm It is nucleoplasmic through most of the cell cycle and associates with replication foci during S-phase. In germ cells, spermatogonia, preleptotene and leptotene spermatocytes all express high levels of nuclear protein, while the protein is not detected in pachytene spermatocytes, despite the fact they expressed high levels of mRNA. In females, the protein is not detected in non-growing oocytes, in contrast to the growing oocytes. During the growing, the protein is no longer detectable in nuclei but accumulates to very high levels first throughout the cytoplasm. At the time of ovulation, all the protein is cytoplasmic and is actively associated with the oocyte cortex. After fecondation, in the preimplantation embryo, the protein remains cytoplasmic and after implantation, it is exclusively nuclear in all tissue types. Isoform 2 is sequestered in the cytoplasm of maturing oocytes and of preimplantation embryos, except for the 8-cell stage, while isoform 1 is exclusively nuclear.
Detection Range	0.312-20ng/mL
Entryname	DNMT1_MOUSE
Method Type	Sandwich
Platform	PF01426
Protein Name	DNA (cytosine-5)-methyltransferase 1
Sensitivity	0.165ng/mL
Sequence	50: MPARTAPARV ; PALASPAGSL ; PDHVRRRLKD ; LERDGLTEKE ; CVREKLNLLH ; 100: EFLQTEIKSQ ; LCDLETKLHK ; EELSEEGYLA ; KVKSLLNKDL ; SLENGTHTLT ; 150: QKANGCPANG ; SRPTWRAEMA ; DSNRSPRSRP ; KPRGPRRSKS ; DSDTLSVETS ; 200: PSSVATRRTT ; RQTTITAHFT ; KGPTKRKPKE ; ESEEGNSAES ; AAEERDQDKK ; 250: RRVVDTESGA ; AAAVEKLEEV ; TAGTQLGPEE ; PCEQEDDNRS ; LRRHTRELSL ; 300: RRKSKEDPDR ; EARPETHLDE ; DEDGKKDKRS ; SRPRSQPRDP ; AAKRRPKEAE ; 350: PEQVAPETPE ; DRDEDEREEK ; RRKTTRKKLE ; SHTVPVQSRS ; ERKAAQSKSV ; 400: IPKINSPKCP ; ECGQHLDDPN ; LKYQQHPEDA ; VDEPQMLTSE ; KLSIYDSTST ; 450: WFDTYEDSPM ; HRFTSFSVYC ; SRGHLCPVDT ; GLIEKNVELY ; FSGCAKAIHD ; 500: ENPSMEGGIN ; GKNLGPINQW ; WLSGFDGGEK ; VLIGFSTAFA ; EYILMEPSKE ; 550: YEPIFGLMQE ; KIYISKIVVE ; FLQNNPDAVY ; EDLINKIETT ; VPPSTINVNR ; 600: FTEDSLLRHA ; QFVVSQVESY ; DEAKDDDETP ; IFLSPCMRAL ; IHLAGVSLGQ ; 650: RRATRRVMGA ; TKEKDKAPTK ; ATTTKLVYQI ; FDTFFSEQIE ; KYDKEDKENA ; 700: MKRRRCGVCE ; VCQQPECGKC ; KACKDMVKFG ; GTGRSKQACL ; KRRCPNLAVK ; 750: EADDDEEADD ; DVSEMPSPKK ; LHQGKKKKQN ; KDRISWLGQP ; MKIEENRTYY ; 800: QKVSIDEEML ; EVGDCVSVIP ; DDSSKPLYLA ; RVTALWEDKN ; GQMMFHAHWF ; 850: CAGTDTVLGA ; TSDPLELFLV ; GECENMQLSY ; IHSKVKVIYK ; APSENWAMEG ; 900: GTDPETTLPG ; AEDGKTYFFQ ; LWYNQEYARF ; ESPPKTQPTE ; DNKHKFCLSC ; 950: IRLAELRQKE ; MPKVLEQIEE ; VDGRVYCSSI ; TKNGVVYRLG ; DSVYLPPEAF ; 1000: TFNIKVASPV ; KRPKKDPVNE ; TLYPEHYRKY ; SDYIKGSNLD ; APEPYRIGRI ; 1050: KEIHCGKKKG ; KVNEADIKLR ; LYKFYRPENT ; HRSYNGSYHT ; DINMLYWSDE ; 1100: EAVVNFSDVQ ; GRCTVEYGED ; LLESIQDYSQ ; GGPDRFYFLE ; AYNSKTKNFE ; 1150: DPPNHARSPG ; NKGKGKGKGK ; GKGKHQVSEP ; KEPEAAIKLP ; KLRTLDVFSG ; 1200: CGGLSEGFHQ ; AGISETLWAI ; EMWDPAAQAF ; RLNNPGTTVF ; TEDCNVLLKL ; 1250: VMAGEVTNSL ; GQRLPQKGDV ; EMLCGGPPCQ ; GFSGMNRFNS ; RTYSKFKNSL ; 1300: VVSFLSYCDY ; YRPRFFLLEN ; VRNFVSYRRS ; MVLKLTLRCL ; VRMGYQCTFG ; 1350: VLQAGQYGVA ; QTRRRAIILA ; AAPGEKLPLF ; PEPLHVFAPR ; ACQLSVVVDD ; 1400: KKFVSNITRL ; SSGPFRTITV ; RDTMSDLPEI ; QNGASNSEIP ; YNGEPLSWFQ ; 1450: RQLRGSHYQP ; ILRDHICKDM ; SPLVAARMRH ; IPLFPGSDWR ; DLPNIQVRLG ; 1500: DGVIAHKLQY ; TFHDVKNGYS ; STGALRGVCS ; CAEGKACDPE ; SRQFSTLIPW ; 1550: CLPHTGNRHN ; HWAGLYGRLE ; WDGFFSTTVT ; NPEPMGKQGR ; VLHPEQHRVV ; 1600: SVRECARSQG ; FPDSYRFFGN ; ILDRHRQVGN ; AVPPPLAKAI ; GLEIKLCLLS ; 1620: SARESASAAV ; KAKEEAATKD ;
Sequence Length	1620
String	P13864
Sub Unit	Homodimer. Interacts with HDAC1 and with PCNA. Binds MBD2 and MBD3. Component of complexes containing SUV39H1. Interacts with DNMT3A and DNMT3B (By similarity). Forms a complex with DMAP1 and HDAC2, with direct interaction. Interacts with the PRC2/EED-EZH2 complex. Interacts with UBC9 (By similarity). Interacts with BAZ2A/TIP5.

Uniprot	P13864
Gene Name	Dnmt1
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:13433
Unigene	Mm.128580

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SKU	Supplier No.	Size	Your price	Quantity
BHE13803603	E2102m	96T	$776		Add to Cart

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