Basement-membrane protein 40 ; BM-40 ; Osteonectin ; ON ; Secreted protein acidic and rich in cysteine ; ON
Categories
Elisa
Function
Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
Specificity
Natural and recombinant Human SPARC
Subcellular Location
Secreted extracellular space extracellular matrix basement membrane In or around the basement membrane.