Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription.
Specificity
Natural and recombinant Human Signal transducer and activator of transcription 5A
Subcellular Location
Cytoplasm Nucleus Translocated into the nucleus in response to phosphorylation.