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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Serine/threonine-protein kinase TAO2

SKU : BHE13810698

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2239h
Alternative Names	Kinase from chicken homolog C ; hKFC-C ; Prostate-derived sterile 20-like kinase 1 ; PSK-1 ; Thousand and one amino acid protein kinase 2 ; KIAA0881 ; MAP3K17 ; PSK ; PSK1 ; UNQ2971/PRO7431
Categories	Elisa
Function	Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in tu phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointealization. Both isoforms are involved in MAPK14 phosphorylation.
Specificity	Natural and recombinant Human Serine/threonine-protein kinase TAO2
Subcellular Location	Isoform 2 Cell projection dendrite In dendrites, colocalizes with PCDH8.
Detection Range	0.156-10ug/mL
Entryname	TAOK2_HUMAN
Method Type	Sandwich
Platform	PF00069
Protein Name	Serine/threonine-protein kinase TAO2
Sensitivity	0.078ug/mL
Sequence	50: MPAGGRAGSL ; KDPDVAELFF ; KDDPEKLFSD ; LREIGHGSFG ; AVYFARDVRN ; 100: SEVVAIKKMS ; YSGKQSNEKW ; QDIIKEVRFL ; QKLRHPNTIQ ; YRGCYLREHT ; 150: AWLVMEYCLG ; SASDLLEVHK ; KPLQEVEIAA ; VTHGALQGLA ; YLHSHNMIHR ; 200: DVKAGNILLS ; EPGLVKLGDF ; GSASIMAPAN ; SFVGTPYWMA ; PEVILAMDEG ; 250: QYDGKVDVWS ; LGITCIELAE ; RKPPLFNMNA ; MSALYHIAQN ; ESPVLQSGHW ; 300: SEYFRNFVDS ; CLQKIPQDRP ; TSEVLLKHRF ; VLRERPPTVI ; MDLIQRTKDA ; 350: VRELDNLQYR ; KMKKILFQEA ; PNGPGAEAPE ; EEEEAEPYMH ; RAGTLTSLES ; 400: SHSVPSMSIS ; ASSQSSSVNS ; LADASDNEEE ; EEEEEEEEEE ; EEGPEAREMA ; 450: MMQEGEHTVT ; SHSSIIHRLP ; GSDNLYDDPY ; QPEITPSPLQ ; PPAAPAPTST ; 500: TSSARRRAYC ; RNRDHFATIR ; TASLVSRQIQ ; EHEQDSALRE ; QLSGYKRMRR ; 550: QHQKQLLALE ; SRLRGEREEH ; SARLQRELEA ; QRAGFGAEAE ; KLARRHQAIG ; 600: EKEARAAQAE ; ERKFQQHILG ; QQKKELAALL ; EAQKRTYKLR ; KEQLKEELQE ; 650: NPSTPKREKA ; EWLLRQKEQL ; QQCQAEEEAG ; LLRRQRQYFE ; LQCRQYKRKM ; 700: LLARHSLDQD ; LLREDLNKKQ ; TQKDLECALL ; LRQHEATREL ; ELRQLQAVQR ; 750: TRAELTRLQH ; QTELGNQLEY ; NKRREQELRQ ; KHAAQVRQQP ; KSLKVRAGQR ; 800: PPGLPLPIPG ; ALGPPNTGTP ; IEQQPCSPGQ ; EAVLDQRMLG ; EEEEAVGERR ; 850: ILGKEGATLE ; PKQQRILGEE ; SGAPSPSPQK ; HGSLVDEEVW ; GLPEEIEELR ; 900: VPSLVPQERS ; IVGQEEAGTW ; SLWGKEDESL ; LDEEFELGWV ; QGPALTPVPE ; 950: EEEEEEEGAP ; IGTPRDPGDG ; CPSPDIPPEP ; PPTHLRPCPA ; SQLPGLLSHG ; 1000: LLAGLSFAVG ; SSSGLLPLLL ; LLLLPLLAAQ ; GGGGLQAALL ; ALEVGLVGLG ; 1050: ASYLLLCTAL ; HLPSSLFLLL ; AQGTALGAVL ; GLSWRRGLMG ; VPLGLGAAWL ; 1100: LAWPGLALPL ; VAMAAGGRWV ; RQQGPRVRRG ; ISRLWLRVLL ; RLSPMAFRAL ; 1150: QGCGAVGDRG ; LFALYPKTNK ; DGFRSRLPVP ; GPRRRNPRTT ; QHPLALLARV ; 1200: WVLCKGWNWR ; LARASQGLAS ; HLPPWAIHTL ; ASWGLLRGER ; PTRIPRLLPR ; 1235: SQRQLGPPAS ; RQPLPGTLAG ; RRSRTRQSRA ; LPPWR
Sequence Length	1235
String	Q9UL54
Sub Unit	Interacts with MAP2K3 and MAP2K6 (By similarity). Self-associates. Interacts with tubulins through the C-terminal domain. Interacts with MAP3K7 and interfers with MAP3K7-binding to CHUK and thus prevents NF-kappa-B activation. Isoform 2 interacts with PCDH8; this complex may also include CDH2.

Uniprot	Q9UL54
Gene Name	TAOK2
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:9344
Unigene	Hs.291623

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810698	E2239h	96T	$736		Add to Cart

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