ELISA Kit for Human R-spondin-1

Mfr.No.	E3285h
Alternative Names	Roof plate-specific spondin-1 ; hRspo1
Categories	Elisa
Function	Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination.
Specificity	Natural and recombinant Human R-spondin-1
Subcellular Location	Secreted
Detection Range	78-5000pg/mL
Entryname	RSPO1_HUMAN
Method Type	Sandwich
Platform	PF00090
Protein Name	R-spondin-1
Sensitivity	43pg/mL
Sequence	50: MRLGLCVVAL ; VLSWTHLTIS ; SRGIKGKRQR ; RISAEGSQAC ; AKGCELCSEV ; 100: NGCLKCSPKL ; FILLERNDIR ; QVGVCLPSCP ; PGYFDARNPD ; MNKCIKCKIE ; 150: HCEACFSHNF ; CTKCKEGLYL ; HKGRCYPACP ; EGSSAANGTM ; ECSSPAQCEM ; 200: SEWSPWGPCS ; KKQQLCGFRR ; GSEERTRRVL ; HAPVGDHAAC ; SDTKETRRCT ; 250: VRRVPCPEGQ ; KRRKGGQGRR ; ENANRNLARK ; ESKEAGAGSR ; RRKGQQQQQQ ; 263: QGTVGPLTSA ; GPA
Sequence Length	263
String	Q2MKA7
Sub Unit	Interacts with the extracelular domain of FZD8 and LRP6. It however does not form a teary complex with FZD8 and LRP6. Interacts with WNT1. Binds heparin.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13809940	E3285h	96T	$563.11		Add to Cart