Participates in O-mannosyl glycosylation. May be responsible for the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins. Is specific for alpha linked terminal mannose and does not have MGAT3, MGAT4, MGAT5, MGAT7 or MGAT8 activity.
Specificity
Natural and recombinant Human Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1
Subcellular Location
Golgi apparatus membrane Single-pass type II membrane protein