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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Proteasome subunit beta type-8

SKU : BHE13808500

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E11791h
Alternative Names	Low molecular mass protein 7 ; Macropain subunit C13 ; Multicatalytic endopeptidase complex subunit C13 ; Proteasome component C13 ; Proteasome subunit beta-5i ; Really interesting new gene 10 protein ; LMP7 ; PSMB5i ; RING10 ; Y2
Categories	Elisa
Function	The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency.
Specificity	Natural and recombinant Human Proteasome subunit beta type-8
Subcellular Location	Cytoplasm Nucleus
Detection Range	0.156-10ng/mL
Entryname	PSB8_HUMAN
Method Type	Sandwich
Platform	PF00227
Protein Name	Proteasome subunit beta type-8
Sensitivity	0.06ng/mL
Sequence	50: MALLDVCGAP ; RGQRPESALP ; VAGSGRRSDP ; GHYSFSMRSP ; ELALPRGMQP ; 100: TEFFQSLGGD ; GERNVQIEMA ; HGTTTLAFKF ; QHGVIAAVDS ; RASAGSYISA ; 150: LRVNKVIEIN ; PYLLGTMSGC ; AADCQYWERL ; LAKECRLYYL ; RNGERISVSA ; 200: ASKLLSNMMC ; QYRGMGLSMG ; SMICGWDKKG ; PGLYYVDEHG ; TRLSGNMFST ; 250: GSGNTYAYGV ; MDSGYRPNLS ; PEEAYDLGRR ; AIAYATHRDS ; YSGGVVNMYH ; 276: MKEDGWVKVE ; STDVSDLLHQ ; YREANQ
Sequence Length	276
String	P28062
Sub Unit	The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. This subunit is part of the immunoproteasome where it displaces the equivalent housekeeping subunit PSMB5. Directly interacts with POMP. Interacts with HIV-1 TAT protein. Interacts with TAP1.

Uniprot	P28062
Gene Name	PSMB8
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:5696
Unigene	Hs.180062

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SKU	Supplier No.	Size	Your price	Quantity
BHE13808500	E11791h	96T	$736		Add to Cart

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