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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Nuclear receptor coactivator 1

SKU : BHE13808476

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0335h
Alternative Names	Class E basic helix-loop-helix protein 74 ; bHLHe74 ; Protein Hin-2 ; RIP160 ; Renal carcinoma antigen NY-REN-52 ; Steroid receptor coactivator 1 ; SRC-1 ; BHLHE74 ; SRC1
Categories	Elisa
Function	Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.
Specificity	Natural and recombinant Human Nuclear receptor coactivator 1
Subcellular Location	Nucleus
Detection Range	0.156-10ng/mL
Entryname	NCOA1_HUMAN
Method Type	Sandwich
Platform	PF07469
Protein Name	Nuclear receptor coactivator 1
Sensitivity	0.056ng/mL
Sequence	50: MSGLGDSSSD ; PANPDSHKRK ; GSPCDTLASS ; TEKRRREQEN ; KYLEELAELL ; 100: SANISDIDSL ; SVKPDKCKIL ; KKTVDQIQLM ; KRMEQEKSTT ; DDDVQKSDIS ; 150: SSSQGVIEKE ; SLGPLLLEAL ; DGFFFVVNCE ; GRIVFVSENV ; TSYLGYNQEE ; 200: LMNTSVYSIL ; HVGDHAEFVK ; NLLPKSLVNG ; VPWPQEATRR ; NSHTFNCRML ; 250: IHPPDEPGTE ; NQEACQRYEV ; MQCFTVSQPK ; SIQEDGEDFQ ; SCLICIARRL ; 300: PRPPAITGVE ; SFMTKQDTTG ; KIISIDTSSL ; RAAGRTGWED ; LVRKCIYAFF ; 350: QPQGREPSYA ; RQLFQEVMTR ; GTASSPSYRF ; ILNDGTMLSA ; HTKCKLCYPQ ; 400: SPDMQPFIMG ; IHIIDREHSG ; LSPQDDTNSG ; MSIPRVNPSV ; NPSISPAHGV ; 450: ARSSTLPPSN ; SNMVSTRINR ; QQSSDLHSSS ; HSNSSNSQGS ; FGCSPGSQIV ; 500: ANVALNQGQA ; SSQSSNPSLN ; LNNSPMEGTG ; ISLAQFMSPR ; RQVTSGLATR ; 550: PRMPNNSFPP ; NISTLSSPVG ; MTSSACNNNN ; RSYSNIPVTS ; LQGMNEGPNN ; 600: SVGFSASSPV ; LRQMSSQNSP ; SRLNIQPAKA ; ESKDNKEIAS ; ILNEMIQSDN ; 650: SSSDGKPLDS ; GLLHNNDRLS ; DGDSKYSQTS ; HKLVQLLTTT ; AEQQLRHADI ; 700: DTSCKDVLSC ; TGTSNSASAN ; SSGGSCPSSH ; SSLTERHKIL ; HRLLQEGSPS ; 750: DITTLSVEPD ; KKDSASTSVS ; VTGQVQGNSS ; IKLELDASKK ; KESKDHQLLR ; 800: YLLDKDEKDL ; RSTPNLSLDD ; VKVKVEKKEQ ; MDPCNTNPTP ; MTKPTPEEIK ; 850: LEAQSQFTAD ; LDQFDQLLPT ; LEKAAQLPGL ; CETDRMDGAV ; TSVTIKSEIL ; 900: PASLQSATAR ; PTSRLNRLPE ; LELEAIDNQF ; GQPGTGDQIP ; WTNNTVTAIN ; 950: QSKSEDQCIS ; SQLDELLCPP ; TTVEGRNDEK ; ALLEQLVSFL ; SGKDETELAE ; 1000: LDRALGIDKL ; VQGGGLDVLS ; ERFPPQQATP ; PLIMEERPNL ; YSQPYSSPSP ; 1050: TANLPSPFQG ; MVRQKPSLGT ; MPVQVTPPRG ; AFSPGMGMQP ; RQTLNRPPAA ; 1100: PNQLRLQLQQ ; RLQGQQQLIH ; QNRQAILNQF ; AATAPVGINM ; RSGMQQQITP ; 1150: QPPLNAQMLA ; QRQRELYSQQ ; HRQRQLIQQQ ; RAMLMRQQSF ; GNNLPPSSGL ; 1200: PVQMGNPRLP ; QGAPQQFPYP ; PNYGTNPGTP ; PASTSPFSQL ; AANPEASLAN ; 1250: RNSMVSRGMT ; GNIGGQFGTG ; INPQMQQNVF ; QYPGAGMVPQ ; GEANFAPSLS ; 1300: PGSSMVPMPI ; PPPQSSLLQQ ; TPPASGYQSP ; DMKAWQQGAI ; GNNNVFSQAV ; 1350: QNQPTPAQPG ; VYNNMSITVS ; MAGGNTNVQN ; MNPMMAQMQM ; SSLQMPGMNT ; 1400: VCPEQINDPA ; LRHTGLYCNQ ; LSSTDLLKTE ; ADGTQQVQQV ; QVFADVQCTV ; 1441: NLVGGDPYLN ; QPGPLGTQKP ; TSGPQTPQAQ ; QKSLLQQLLT ; E
Sequence Length	1441
String	Q15788
Sub Unit	Interacts with the methyltransferase CARM1 (By similarity). Interacts with NCOA6 and NCOA2. Interacts with the FDL motif of STAT5A and STAT5B. Interacts with the LXXLL motif of STAT6. Interacts with STAT3 following IL-6 stimulation. Interacts with the basal transcription factor GTF2B. Interacts with the histone acetyltransferases EP300 and CREBBP. Interacts with PCAF, COPS5, NR3C1 and TTLL5/STAMP. Interacts with PSMB9. Interacts with UBE2L3; they functionally interact to regulate progesterone receptor transcriptional activity. Interacts with PRMT2.

Uniprot	Q15788
Gene Name	NCOA1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:8648
Unigene	Hs.596314

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SKU	Supplier No.	Size	Your price	Quantity
BHE13808476	E0335h	96T	$736		Add to Cart

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