Activates progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin.
Specificity
Natural and recombinant Human Matrix metalloproteinase-24
Subcellular Location
Processed matrix metalloproteinase-24 Secreted extracellular space extracellular matrix Also shed from cell surface as soluble proteinase, by a proteolytic cleavage.
"Identification of a new membrane-type matrix metalloproteinase, MT5-MMP, that is expressed predominantly in cerebellum." Seiki M. Submitted (1998-12) to the EMBL/GenBank/DDBJ databases
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