MHC class II antigen DMA ; Really interesting new gene 6 protein ; DMA ; RING6
Categories
Elisa
Function
Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.
Specificity
Natural and recombinant Human HLA class II histocompatibility antigen, DM alpha chain
Subcellular Location
Late endosome membrane Single-pass type I membrane protein Lysosome membrane Single-pass type I membrane protein Localizes to late endocytic compartment. Associates with lysosome membranes.