ELISA Kit for Human Hepatitis A virus cellular receptor 1

Mfr.No.

E0785h

Alternative Names

Kidney injury molecule 1 ; KIM-1 ; T-cell immunoglobulin and mucin domain-containing protein 1 ; TIMD-1 ; T-cell immunoglobulin mucin receptor 1 ; TIM ; T-cell membrane protein 1 ; KIM1 ; TIM1 ; TIMD1

Categories

Elisa

Function

May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4 (By similarity). In case of human hepatitis A virus (HHAV) infection, functions as a cell-surface receptor for the virus. May play a role in kidney injury and repair.

Specificity

Natural and recombinant Human Hepatitis A virus cellular receptor 1

Subcellular Location

Membrane Single-pass type I membrane protein

Detection Range

0.156-10ng/mL

Entryname

HAVR1_HUMAN

Linearity

The linearity of the kit was assayed by testing samples spiked with appropriate concentration of HAVcr-1 and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample	1：2	1:4	1:8	1:16
serum(n=5)	89-93%	89-101%	86-99%	93-102%
EDTA plasma(n=5)	92-104%	88-101%	82-93%	86-91%
heparin plasma(n=5)	86-98%	84-95%	83-92%	90-103%

Method Type

Sandwich

Platform

PF07686

Precision

Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤3.6%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤6.9%

Protein Name

Hepatitis A virus cellular receptor 1

Recovery

Recovery was determined by spiking various levels of HAVcr-1 into serum and plasma .

Sample Type	Average(%)	Recovery Range (%)
Serum	95	92-98
Plasma	89	86-93

Sensitivity

0.1ng/mL

Sequence

50:

MHPQVVILSL ; ILHLADSVAG ; SVKVGGEAGP ; SVTLPCHYSG ; AVTSMCWNRG ;

100:

SCSLFTCQNG ; IVWTNGTHVT ; YRKDTRYKLL ; GDLSRRDVSL ; TIENTAVSDS ;

150:

GVYCCRVEHR ; GWFNDMKITV ; SLEIVPPKVT ; TTPIVTTVPT ; VTTVRTSTTV ;

200:

PTTTTVPTTT ; VPTTMSIPTT ; TTVLTTMTVS ; TTTSVPTTTS ; IPTTTSVPVT ;

250:

TTVSTFVPPM ; PLPRQNHEPV ; ATSPSSPQPA ; ETHPTTLQGA ; IRREPTSSPL ;

300:

YSYTTDGNDT ; VTESSDGLWN ; NNQTQLFLEH ; SLLTANTTKG ; IYAGVCISVL ;

350:

VLLALLGVII ; AKKYFFKKEV ; QQLSVSFSSL ; QIKALQNAVE ; KEVQAEDNIY ;

359:

IENSLYATD

Sequence Length

359

String

Q96D42

Uniprot	Q96D42
Gene Name	HAVCR1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:26762
Unigene	Hs.129711

Reference	1. "The human homolog of HAVcr-1 codes for a hepatitis A virus cellular receptor." Feigelstock D., Thompson P., Mattoo P., Zhang Y., Kaplan G.G. J. Virol.72:6621-6628(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION AS A HAV RECEPTOR;TISSUE SPECIFICITY tissue: Liver. 2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Ko B. Submitted (2004-06) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT MET-THR-THR-VAL-PRO-157 INS 3. "The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S., Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.more... Nature431:268-274(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] 4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT MET-THR-THR-VAL-PRO-157 INS tissue: Kidney. 5. "Immunoglobulin A (IgA) is a natural ligand of hepatitis A virus cellular receptor 1 (HAVCR1), and the association of IgA with HAVCR1 enhances virus-receptor interactions." Tami C., Silberstein E., Manangeeswaran M., Freeman G.J., Umetsu S.E., DeKruyff R.H., Umetsu D.T., Kaplan G.G. J. Virol.81:3437-3446(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IMMUNOGLUBULIN A 6. "Tubular kidney injury molecule-1 (KIM-1) in human renal disease." van Timmeren M.M., van den Heuvel M.C., Bailly V., Bakker S.J., van Goor H., Stegeman C.A. J. Pathol.212:209-217(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION 7. "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] tissue: Cervix carcinoma. 8. "Hepatitis A virus link to atopic disease." McIntire J.J., Umetsu S.E., Macaubas C., Hoyte E.G., Cinnioglu C., Cavalli-Sforza L.L., Barsh G.S., Hallmayer J.F., Underhill P.A., Risch N.J., Freeman G.J., DeKruyff R.H., Umetsu D.T. Nature425:576-576(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MET-THR-THR-THR-VAL-PRO-157 INS AND THR-195 DEL 9. Umetsu D.T. Submitted (2005-09) to the UniProtKB [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MET-THR-THR-VAL-PRO-157 INS

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ELISA Kit for Human Hepatitis A virus cellular receptor 1

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