35 kDa lectin ; Carbohydrate-binding protein 35 ; CBP 35 ; Galactose-specific lectin 3 ; Galactoside-binding protein ; GALBP ; IgE-binding protein ; L-31 ; Laminin-binding protein ; Lectin L-29 ; Mac-2 antigen ; MAC2
Categories
Elisa
Function
Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.
Specificity
Natural and recombinant Human Galectin-3
Subcellular Location
Cytoplasm Nucleus Secreted Secreted by a non-classical secretory pathway and associates with the cell surface.
Probably forms homo- or heterodimers. Interacts with DMBT1 (By similarity). Forms a complex with the ITGA3, ITGB1 and CSPG4. Interacts with LGALS3BP, LYPD3, CYHR1 and UACA.