Blood group Lewis alpha-4-fucosyltransferase ; Lewis FT ; Fucosyltransferase 3 ; Fucosyltransferase III ; FucT-III ; FT3B ; LE
Categories
Elisa
Function
May catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of Vim-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination; Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme. Also acts on the corresponding 1,4-galactosyl derivative, forming 1,3-L-fucosyl links.
Specificity
Natural and recombinant Human Galactoside 3(4)-L-fucosyltransferase
Subcellular Location
Golgi apparatus Golgi stack membrane Single-pass type II membrane protein Membrane-bound form in trans cisteae of Golgi.