Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis.
Specificity
Natural and recombinant Human Ezrin
Subcellular Location
Apical cell membrane Peripheral membrane protein Cytoplasmic side Cell projection Cell projection microvillus membrane Peripheral membrane protein Cytoplasmic side Cell projection ruffle membrane Peripheral membrane protein Cytoplasmic side Cytoplasm cell cortex Cytoplasm cytoskeleton Localization to the apical membrane of parietal cells depends on the interaction with MPP5. Localizes to cell extensions and peripheral processes of astrocytes (By similarity). Microvillar peripheral membrane protein.
Interacts with MPP5 and SLC9A3R2. Found in a complex with EZR, PODXL and SLC9A3R2 (By similarity). Interacts with MCC, PLEKHG6, PODXL, SCYL3/PACE1, SLC9A3R1 and TMEM8B. Interacts (when phosphorylated) with FES/FPS.