ELISA Kit for Human Dickkopf-related protein 1

Mfr.No.	E0741h
Alternative Names	SK ; UNQ492/PRO1008
Categories	Elisa
Function	Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a teary complex with the transmembrane protein KREMEN that promotes intealization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patteing, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Specificity	Natural and recombinant Human Dickkopf-related protein 1
Subcellular Location	Secreted
Detection Range	78-5000pg/mL
Entryname	DKK1_HUMAN
Method Type	Sandwich
Platform	PF04706
Protein Name	Dickkopf-related protein 1
Sensitivity	31pg/mL
Sequence	50: MMALGAAGAT ; RVFVAMVAAA ; LGGHPLLGVS ; ATLNSVLNSN ; AIKNLPPPLG ; 100: GAAGHPGSAV ; SAAPGILYPG ; GNKYQTIDNY ; QPYPCAEDEE ; CGTDEYCASP ; 150: TRGGDAGVQI ; CLACRKRRKR ; CMRHAMCCPG ; NYCKNGICVS ; SDQNHFRGEI ; 200: EETITESFGN ; DHSTLDGYSR ; RTTLSSKMYH ; TKGQEGSVCL ; RSSDCASGLC ; 250: CARHFWSKIC ; KPVLKEGQVC ; TKHRRKGSHG ; LEIFQRCYCG ; EGLSCRIQKD ; 266: HHQASNSSRL ; HTCQRH
Sequence Length	266
String	O94907
Sub Unit	Interacts with LRP6. Interacts (via the C-termianl Cys-rich domain) with LRP5 (via beta-propeller regions 3 and 4); the interaction, enhanced by MESD and or KREMEN, antagonizes Wnt-mediated signaling.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13812120	E0741h	96T	$536		Add to Cart