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Home / Primary Antibodies / Polyclonal Antibodies

ZRANB3 antibody

SKU : BHA10809726

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Mfr.No.	FNab09756
Alternative Names	DNAannealinghelicaseandendonucleaseZRANB3 ; Annealinghelicase2 ; AH2
Background	DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks.
Categories	Primary Antibodies
Cellular Localization	Chromosome, Nucleus
Clonality	polyclonal
Description	DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks.
Host	Rabbit
Immunogen	zinc finger, RAN-binding domain containing 3
Isotype	IgG
Molecular Weight	150 kDa and 50 kDa
Reactivity	Human
Regulatory	RUO
Subcellular Location	Chromosome, Nucleus
Synonyms	DNA annealing helicase and endonuclease ZRANB3,Annealing helicase 2,AH2

Uniprot	Q5FWF4
Gene Id	84083
Research Area	Metabolism
Weight	123kDa,observed 150kDa and 50kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB

Description

ELISA ; WB

Dilution

WB	1:200-1:2000
IF	1:20-1:200

Tested Application

WB: 1:200-1:2000; IF: 1:20-1:200

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SKU	Supplier No.	Size	Your price	Quantity
BHA10809726	FNab09756	100ug	$280		Add to Cart

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