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Home / Primary Antibodies / Polyclonal Antibodies

ZO-1 antibody

SKU : BHA10809721

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Mfr.No.	FNab09751
Alternative Names	Tightjunctionprotein1 ; TightjunctionproteinZO1 ; TJP1 ; ZO1 ; ZO1 ; ZO-1 ; Zonaoccludensprotein1 ; Zonulaoccludensprotein1
Background	Tight junction(or zonula occludens) form the continuous intercellular barrier between epithelial and endothelial cells, which is required to separate tissue spaces and regulate selective movement of solutes across the epithelium and endothelium(PMID: 20066090). ZO-1(also known as TJP1) is a peripheral membrane phosphoprotein located on the cytoplasmic face and is expressed in tight junctions of both epithelial and endothelial cells(PMID: 3528172). It binds the transmembrane proteins occludin and the claudins linking them to cytoskeletal actin(PMID: 17418867). ZO-1 belongs to a family of multidomain proteins known as the membrane-associated guanylate kinase homologs(MAGUKs). It is a pivotal tight junction protein and may be involved in signalling mechanisms regulating cell proliferation and differentiation(PMID: 22782886).
Categories	Primary Antibodies
Cellular Localization	Cell Junction, Membrane
Clonality	polyclonal
Description	Tight junction (or zonula occludens) form the continuous intercellular barrier between epithelial and endothelial cells, which is required to separate tissue spaces and regulate selective movement of solutes across the epithelium and endothelium (PMID: 20066090). ZO-1 (also known as TJP1) is a peripheral membrane phosphoprotein located on the cytoplasmic face and is expressed in tight junctions of both epithelial and endothelial cells (PMID: 3528172). It binds the transmembrane proteins occludin and the claudins linking them to cytoskeletal actin (PMID: 17418867). ZO-1 belongs to a family of multidomain proteins known as the membrane-associated guanylate kinase homologs (MAGUKs). It is a pivotal tight junction protein and may be involved in signalling mechanisms regulating cell proliferation and differentiation (PMID: 22782886).
Host	Rabbit
Immunogen	tight junction protein 1(zona occludens 1)
Isotype	IgG
Molecular Weight	230kd
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Subcellular Location	Cell junction, Cell membrane
Synonyms	Tight junction protein 1, Tight junction protein ZO 1, TJP1, ZO 1, ZO1, ZO-1, Zona occludens protein 1, Zonula occludens protein 1

Uniprot	Q07157
Gene Id	7082
Research Area	Neuroscience
Weight	195kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IHC, FC, IF, IP

Description

ELISA ; WB ; IHC ; FC ; IF ; IP

Dilution

WB	1:200-1:2000
IP	1:200-1:2000
IHC	1:50-1:200
IF	1:20-1:200

Tested Application

WB: 1:200-1:2000; IP: 1:200-1:2000; IHC: 1:50-1:200; IF: 1:20-1:200

Manual	FNab09751.pdf

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10809721	FNab09751	100ug	$280		Add to Cart

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