Mediates transcriptional repression in response to zinc. Represses several genes, including SLC30A5, SLC30A10 and CBWD1, by binding to the zinc transcriptional regulatory element(ZTRE)(5'-C(AC)C(TAG)CC(TC)-N(0-50)-(GA)G(ATC)G(TG)G-3') found in the promoter region. May play a role in the control of ribosome biogenesis, regulating predominantly rRNA levels, as well as those of several ribosomal proteins, thus coordinating this highly zinc-demanding process with the available zinc supply.
Categories
Primary Antibodies
Clonality
polyclonal
Description
Mediates transcriptional repression in response to zinc. Represses several genes, including SLC30A5, SLC30A10 and CBWD1, by binding to the zinc transcriptional regulatory element (ZTRE) (5'- C[AC]C[TAG]CC[TC]-N(0-50)-[GA]G[ATC]G[TG]G-3') found in the promoter region. May play a role in the control of ribosome biogenesis, regulating predominantly rRNA levels, as well as those of several ribosomal proteins, thus coordinating this highly zinc- demanding process with the available zinc supply.
Host
Rabbit
Immunogen
zinc finger protein 658
Isotype
IgG
Molecular Weight
71 kDa
Reactivity
Human, Rat
Regulatory
RUO
Synonyms
DKFZp572C163, FLJ32813, zinc finger protein 658, ZNF658
Uniprot
Q5TYW1
Gene Id
26149
Research Area
Metabolism
Weight
122kDa,observed 71kDa
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)