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Home / Primary Antibodies / Polyclonal Antibodies

YBX1 antibody

SKU : BHA10809532

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Mfr.No.	FNab09561
Alternative Names	BP8 ; CBFA ; CSDA2 ; CSDB ; DBPB ; DNAbindingproteinB ; EFIA ; EnhancerfactorIsubunitA ; MDRNF1 ; NSEP1 ; NSEP1
Background	This gene encodes a highly conserved cold shock domain protein that has broad nucleic acid binding properties. The encoded protein functions as both a DNA and RNA binding protein and has been implicated in numerous cellular processes including regulation of transcription and translation, pre-mRNA splicing, DNA reparation and mRNA packaging. This protein is also a component of messenger ribonucleoprotein (mRNP) complexes and may have a role in microRNA processing. This protein can be secreted through non-classical pathways and functions as an extracellular mitogen. Aberrant expression of the gene is associated with cancer proliferation in numerous tissues. This gene may be a prognostic marker for poor outcome and drug resistance in certain cancers. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on multiple chromosomes.
Categories	Primary Antibodies
Cellular Localization	Cytoplasm, Nucleus, Secreted
Clonality	polyclonal
Description	Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role in DNA repair. Component of the CRD-mediated complex that promotes MYC mRNA stability. Binds preferentially to the 5'-[CU]CUGCG-3' motif in vitro. The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation.
Host	Rabbit
Immunogen	Y box binding protein 1
Isotype	IgG
Molecular Weight	50 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Subcellular Location	Cytoplasm, Nucleus, Secreted
Synonyms	BP 8, CBF A, CSDA2, CSDB, DBPB, DNA binding protein B, EFI A, Enhancer factor I subunit A, MDR NF1, NSEP 1, NSEP1, Y box binding protein 1, Y box transcription factor, YB 1, YB1, YBX1

Uniprot	P67809
Gene Id	4904
Research Area	Metabolism
Weight	36kDa,Observed 50kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IHC, IP, IF

Description

ELISA ; WB ; IHC ; IP ; IF

Dilution

WB	1:500-1:5000
IP	1:200-1:2000
IHC	1:20-1:200
IF	1:20-1:200

Tested Application

WB: 1:500 - 1:2000; IHC: 1:100 - 1:200

Manual	FNab09561.pdf

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10809532	FNab09561	100ug	$280		Add to Cart

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