The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand breaks. This protein plays a role in both non-homologous end joining and the completion of V(D)J recombination. Mutations in this gene can cause short stature, microcephaly, and endocrine dysfunction (SSMED). Alternative splicing generates several transcript variants.
Categories
Primary Antibodies
Cellular Localization
Nucleus
Clonality
polyclonal
Description
Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.
Host
Rabbit
Immunogen
X-ray repair complementing defective repair in Chinese hamster cells 4
Isotype
IgG
Molecular Weight
45 kDa
Reactivity
Human, Rat, Mouse
Regulatory
RUO
Subcellular Location
Nucleus
Synonyms
DNA repair protein XRCC4, XRCC4
Uniprot
Q13426
Gene Id
7518
Research Area
Epigenetics, Metabolism
Weight
38kDa,Observed 55kDa
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)