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Home / Primary Antibodies / Polyclonal Antibodies

XPO7 antibody

SKU : BHA10809522

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Mfr.No.	FNab09551
Alternative Names	Exp7 ; exportin7 ; KIAA0745 ; Ranbindingprotein16 ; RANBP16 ; XPO7
Background	Mediates the nuclear export of proteins(cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex(NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP(induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus.
Categories	Primary Antibodies
Cellular Localization	Cytoplasm, Nuclear Pore Complex, Nucleus
Clonality	polyclonal
Description	Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Host	Rabbit
Immunogen	exportin 7
Isotype	IgG
Molecular Weight	100 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Subcellular Location	Cytoplasm, Nuclear pore complex, Nucleus
Synonyms	Exp7, exportin 7, KIAA0745, Ran binding protein 16, RANBP16, XPO7

Uniprot	Q9UIA9
Gene Id	23039
Research Area	Signal Transduction
Weight	124kDa,Observed 100kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB

Description

ELISA ; WB

Dilution

WB	1:500-1:5000

Tested Application

WB: 1:500-1:5000

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SKU	Supplier No.	Size	Your price	Quantity
BHA10809522	FNab09551	100ug	$240		Add to Cart

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