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Home / Primary Antibodies / Polyclonal Antibodies

VPS33A antibody

SKU : BHA10809410

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Mfr.No.	FNab09435
Alternative Names	FLJ22395 ; FLJ23187 ; hVPS33A ; VPS33A
Background	Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations(PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with VPS16 but not VIPAS39(PubMed:25783203). The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG(PubMed:24554770).
Categories	Primary Antibodies
Cellular Localization	Cytoplasmic Vesicle, Endosome, Lysosome Membrane, Membrane
Clonality	polyclonal
Description	Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with VPS16 but not VIPAS39 (PubMed:25783203). The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG (PubMed:24554770).
Host	Rabbit
Immunogen	vacuolar protein sorting 33 homolog A
Isotype	IgG
Molecular Weight	68 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Subcellular Location	Cytoplasmic vesicle, Endosome, Lysosome, Membrane
Synonyms	FLJ22395, FLJ23187, hVPS33A, VPS33A

Uniprot	Q96AX1
Gene Id	65082
Research Area	Signal Transduction
Weight	68kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB

Description

ELISA ; WB

Dilution

WB	1:500-1:5000
IP	1:200-1:2000

Tested Application

WB: 1:500-1:5000; IP: 1:200-1:2000

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SKU	Supplier No.	Size	Your price	Quantity
BHA10809410	FNab09435	100ug	$260		Add to Cart

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