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Home / Primary Antibodies / Polyclonal Antibodies

VPS18 antibody

SKU : BHA10809404

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Mfr.No.	FNab09429
Alternative Names	HVPS18 ; KIAA1475 ; PEP3 ; VPS18
Background	Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations(PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes(PubMed:25783203). Involved in dendrite development of Pukinje cells(By similarity).
Categories	Primary Antibodies
Cellular Localization	Cytoplasmic Vesicle, Endosome, Lysosome Membrane, Membrane
Clonality	polyclonal
Description	Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in dendrite development of Pukinje cells (By similarity).
Host	Rabbit
Immunogen	vacuolar protein sorting 18 homolog
Isotype	IgG
Molecular Weight	110 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Subcellular Location	Cytoplasmic vesicle, Endosome, Lysosome, Membrane
Synonyms	HVPS18, KIAA1475, PEP3, VPS18

Uniprot	Q9P253
Gene Id	57617
Research Area	Signal Transduction
Weight	110kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, IP, IHC, FC, IF

Description

ELISA ; IP ; IHC ; FC ; IF

Dilution

IHC	1:20-1:200
IP	1:200-1:1000
IF	1:20-1:200

Tested Application

WB: 1:200-1:1000; IHC: 1:50-1:500; IP: 1:200-1:1000; IF: 1:20-1:200

Manual	FNab09429.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10809404	FNab09429	100ug	$260		Add to Cart

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