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Home / Primary Antibodies / Polyclonal Antibodies

VCAM-1 antibody

SKU : BHA10809361

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Mfr.No.	FNab09380
Alternative Names	CD106 ; DKFZp779G2333 ; INCAM100 ; L1CAM ; VCAM1 ; VCAM1 ; VCAM1
Background	This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene.
Categories	Primary Antibodies
Cellular Localization	Membrane
Clonality	polyclonal
Description	Vascular cell adhesion molecule 1 (VCAM1), also known as CD106, is a transmembrane glycoprotein belonging to the immunoglobulin gene superfamily. VCAM1 is expressed by cytokine-activated endothelium, interacts with integrin VLA4 (α4β1) present on the surface of leukocytes, and mediates both adhesion and signal transduction. It is also expressed either constitutively or inducibly in a variety of other cell types, including vascular smooth muscle cells, differentiating skeletal muscle cells, renal and neural epithelial cells, macrophages (Kupffer cells), dendritic cells, and bone marrow stromal cells (PMID: 7507076, 11359843).
Host	Rabbit
Immunogen	vascular cell adhesion molecule 1
Isotype	IgG
Molecular Weight	105 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Subcellular Location	Membrane
Synonyms	CD106, DKFZp779G2333, INCAM 100, L1CAM, V CAM 1, VCAM 1, VCAM1

Uniprot	P19320
Gene Id	7412
Research Area	Signal Transduction, Cardiovascular, Immunology, Cancer, Stem Cells, Neuroscience
Weight	81kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications

ELISA, IHC

Description

ELISA ; IHC

Dilution

IHC	1:100-1:400

Tested Application

WB: 1:1000 - 1:3000; IHC: 1:50 - 1:200

Manual	FNab09380.pdf

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10809361	FNab09380	100ug	$260		Add to Cart

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