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Home / Primary Antibodies / Polyclonal Antibodies

USP16 antibody

SKU : BHA10809296

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Mfr.No.	FNab09312
Alternative Names	Deubiquitinatingenzyme16 ; Ubiquitinthiolesterase16 ; UBPM ; USP16
Background	Specifically deubiquitinates 'Lys-120' of histone H2A(H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3(H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B-and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
Categories	Primary Antibodies
Cellular Localization	Nucleus
Clonality	polyclonal
Description	Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T- lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
Host	Rabbit
Immunogen	ubiquitin specific peptidase 16
Isotype	IgG
Molecular Weight	94 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Subcellular Location	Nucleus
Synonyms	Deubiquitinating enzyme 16, Ubiquitin thiolesterase 16, UBP M, USP16

Uniprot	Q9Y5T5
Gene Id	10600
Research Area	Epigenetics, Metabolism
Weight	94kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IHC, IP

Description

ELISA ; WB ; IHC ; IP

Dilution

WB	1:500-1:5000
IP	1:500-1:5000
IHC	1:20-1:200

Tested Application

WB: 1:500-1:5000; IP: 1:500-1:5000; IHC: 1:20-1:200

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SKU	Supplier No.	Size	Your price	Quantity
BHA10809296	FNab09312	100ug	$260		Add to Cart

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