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Home / Primary Antibodies / Polyclonal Antibodies

UPF3B antibody

SKU : BHA10809259

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Mfr.No.	FNab09272
Alternative Names	HUPF3B ; hUpf3pX ; MRXS14 ; RENT3B ; UPF3B ; UPF3X
Background	Involved in nonsense-mediated decay(NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex(EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex(including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation; the function is independent of association with UPF2 and components of the EJC core.
Categories	Primary Antibodies
Cellular Localization	Cytoplasm, Nucleus
Clonality	polyclonal
Description	Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2- UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation; the function is independent of association with UPF2 and components of the EJC core.
Host	Rabbit
Immunogen	UPF3 regulator of nonsense transcripts homolog B(yeast)
Isotype	IgG
Molecular Weight	58 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Subcellular Location	Cytoplasm, Nucleus
Synonyms	HUPF3B, hUpf3p X, MRXS14, RENT3B, UPF3B, UPF3X

Antigen	UPF3B
Uniprot	Q9BZI7
Gene Id	65109
Research Area	Metabolism
Weight	58kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC

Dilution

WB	1:500-1:5000
IHC	1:20-1:200

Tested Application

WB: 1:500-1:5000; IHC?1:20-1:200

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SKU	Supplier No.	Size	Your price	Quantity
BHA10809259	FNab09272	100ug	$260		Add to Cart

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