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Home / Primary Antibodies / Polyclonal Antibodies

UPF3A antibody

SKU : BHA10809258

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Mfr.No.	FNab09271
Alternative Names	HUpf3 ; HUPF3A ; RENT3A ; UPF3 ; UPF3A
Background	Involved in nonsense-mediated decay(NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex(EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex(including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. However, UPF3A is shown to be only marginally active in NMD as compared to UPF3B. Binds spliced mRNA upstream of exon-exon junctions. In vitro, weakly stimulates translation.
Categories	Primary Antibodies
Cellular Localization	Cytoplasm, Nucleus
Clonality	polyclonal
Description	Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2- UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. However, UPF3A is shown to be only marginally active in NMD as compared to UPF3B. Binds spliced mRNA upstream of exon-exon junctions. In vitro, weakly stimulates translation.
Host	Rabbit
Immunogen	UPF3 regulator of nonsense transcripts homolog A(yeast)
Isotype	IgG
Molecular Weight	51 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Subcellular Location	Cytoplasm, Nucleus
Synonyms	HUpf3, HUPF3A, RENT3A, UPF3, UPF3A

Antigen	UPF3A
Uniprot	Q9H1J1
Gene Id	65110
Research Area	Metabolism
Weight	51kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC

Dilution

WB	1:500-1:5000
IHC	1:20-1:200
IF	1:20-1:200

Tested Application

WB: 1:500-1:5000; IHC?1:20-1:200?IF: 1?20-1?200

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SKU	Supplier No.	Size	Your price	Quantity
BHA10809258	FNab09271	100ug	$260		Add to Cart

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