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Home / Primary Antibodies / Polyclonal Antibodies

uPAR antibody

SKU : BHA10809255

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Mfr.No.	FNab09268
Alternative Names	CD87 ; MO3 ; PLAUR ; UPAR ; UPAR ; URKR
Background	Urokinase plasminogen activator surface receptor(uPAR, also known as PLAUR or CD87) is a 45-65 kDa, highly glycosylated, GPI-anchored membrane protein. It contains three homologous domains(D1-D3) of which the N-terminal one(D1) represents the uPA-binding domain. After binding to uPAR, urokinase plasminogen activator(uPA) cleaves plasminogen, generating the active protease plasmin which is involved in a wide variety of physiologic and pathologic processes. In addition to regulating proteolysis, uPAR has important function in cell adhesion, migration and proliferation. Studies reveal that uPAR expression is elevated during inflammation and tissue remodelling and in many human cancers, in which it frequently indicates poor prognosis.(PMID 20027185; 12461559)
Categories	Primary Antibodies
Clonality	polyclonal
Description	Urokinase plasminogen activator surface receptor (uPAR, also known as PLAUR or CD87) is a 45-65 kDa, highly glycosylated, GPI-anchored membrane protein. It contains three homologous domains (D1-D3) of which the N-terminal one (D1) represents the uPA-binding domain. After binding to uPAR, urokinase plasminogen activator (uPA) cleaves plasminogen, generating the active protease plasmin which is involved in a wide variety of physiologic and pathologic processes. In addition to regulating proteolysis, uPAR has important function in cell adhesion, migration and proliferation. Studies reveal that uPAR expression is elevated during inflammation and tissue remodelling and in many human cancers, in which it frequently indicates poor prognosis. (PMID 20027185; 12461559)
Host	Rabbit
Immunogen	plasminogen activator, urokinase receptor
Isotype	IgG
Molecular Weight	37-70 kDa
Reactivity	Human, Mouse
Regulatory	RUO
Synonyms	CD87, MO3, PLAUR, U PAR, UPAR, URKR

Uniprot	Q03405
Research Area	Immunology, Cardiovascular, Signal Transduction
Weight	37kDa,Observed 70kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IP

Description

ELISA ; WB ; IP

Dilution

WB	1:200-1:2000
IP	1:200-1:1000

Tested Application

WB: 1:200-1:2000; IP: 1:200-1:1000

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SKU	Supplier No.	Size	Your price	Quantity
BHA10809255	FNab09268	100ug	$260		Add to Cart

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