UNC5C, also named as UNC5H3, belongs to the unc-5 family. It is a receptor for netrin required for axon guidance. It mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. The antibody is specific to UNC5C.
Categories
Primary Antibodies
Clonality
polyclonal
Description
UNC5C, also named as UNC5H3, belongs to the unc-5 family. It is a receptor for netrin required for axon guidance. It mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. The antibody is specific to UNC5C.
Host
Rabbit
Immunogen
unc-5 homolog C(C. elegans)
Isotype
IgG
Molecular Weight
103 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Synonyms
UNC5C, unc 5 homolog C(C. elegans), UNC5H3, Protein unc 5 homolog 3, Protein unc 5 homolog C
Uniprot
O95185
Research Area
Developmental biology, Signal Transduction
Weight
103kDa,Observed 50kDa,103kDa
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)