This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants.
Categories
Primary Antibodies
Clonality
polyclonal
Host
Rabbit
Immunogen
uridine monophosphate synthetase
Isotype
IgG
Molecular Weight
55 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Synonyms
OMPdecase, OPRT, OPRTase, UMPS
Uniprot
P11172
Gene Id
7372
Research Area
Metabolism
Weight
52kDa
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)