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Home / Primary Antibodies / Polyclonal Antibodies

ULK1 antibody

SKU : BHA10809240

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Mfr.No.	FNab09251
Alternative Names	ATG1 ; FLJ38455 ; FLJ46475 ; KIAA0722 ; ULK1 ; Unc51likekinase1 ; UNC51 ; Unc51.1
Background	ULK1, also named as KIAA0722, belongs to the protein kinase superfamily, Ser/Thr protein kinase family and APG1/unc-51/ULK1 subfamily. It is involved in autophagy. ULK1 is required for autophagosome formation. It forms a stable complex with Atg13 and focal adhesion kinase(FAK) family interacting protein of 200 kDa(FIP 200)(PMID:21460634). ULK1 phosphorylates ATG13/KIAA0652. It is involved in axon growth. ULK1 plays an essential role in neurite extension of cerebellar granule cells. ULK1 represents a potential novel prognostic biomarker for HCC patients and may play an important role during the progression of HCC(PMID:23573318).
Categories	Primary Antibodies
Cellular Localization	Cytoplasm
Clonality	polyclonal
Description	Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. May also phosphorylate SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165).
Host	Rabbit
Immunogen	unc-51-like kinase 1(C. elegans)
Isotype	IgG
Molecular Weight	150 kDa
Reactivity	Human, Rat
Regulatory	RUO
Subcellular Location	Cytoplasm
Synonyms	ATG1, FLJ38455, FLJ46475, KIAA0722, ULK1, Unc 51 like kinase 1, UNC51, Unc51.1

Uniprot	O75385
Gene Id	8408
Research Area	Developmental biology, Cardiovascular, Metabolism, Signal Transduction
Weight	113kDa,Observed 160kD

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB

Description

ELISA ; WB

Dilution

WB	1:200-1:1000
IHC	1:50-1:500

Tested Application

WB: 1:200-1:1000; IHC: 1?50-1?500

Manual	FNab09251.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10809240	FNab09251	100ug	$280		Add to Cart

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