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Home / Primary Antibodies / Polyclonal Antibodies

ULBP1 antibody

SKU : BHA10809238

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Mfr.No.	FNab09249
Alternative Names	ALCANbeta ; N2DL1 ; N2DL1 ; NKG2Dligand1 ; NKG2DL1 ; RAET1I ; UL16bindingprotein1 ; ULBP1
Background	Ligand for the KLRK1/NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the KLRK1/NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Ligand for the KLRK1/NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the KLRK1/NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.
Host	Rabbit
Immunogen	UL16 binding protein 1
Isotype	IgG
Molecular Weight	30 kDa, 37 kDa
Reactivity	Human, Mouse
Regulatory	RUO
Synonyms	ALCAN beta, N2DL 1, N2DL1, NKG2D ligand 1, NKG2DL1, RAET1I, UL16 binding protein 1, ULBP1

Uniprot	Q9BZM6
Gene Id	80329
Research Area	Cancer
Weight	28kDa,Observed 30kDa,37kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC

Dilution

WB	1:200-1:2000
IHC	1:20-1:200

Tested Application

WB: 1:200-1:2000; IHC: 1?20-1?200

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SKU	Supplier No.	Size	Your price	Quantity
BHA10809238	FNab09249	100ug	$280		Add to Cart

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