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Home / Primary Antibodies / Polyclonal Antibodies

UHRF1 antibody

SKU : BHA10809234

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Mfr.No.	FNab09245
Alternative Names	FLJ21925 ; hNP95 ; HuNp95 ; ICBP90 ; Nuclearprotein95 ; RINGfingerprotein106 ; RNF106 ; TranscriptionfactorICBP90 ; UHRF1
Background	This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12.
Categories	Primary Antibodies
Cellular Localization	Nucleus
Clonality	polyclonal
Description	Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD- type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML. It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo. May be involved in DNA repair.
Host	Rabbit
Immunogen	ubiquitin-like with PHD and ring finger domains 1
Isotype	IgG
Molecular Weight	110 kDa
Reactivity	Human
Regulatory	RUO
Subcellular Location	Nucleus
Synonyms	FLJ21925, hNP95, HuNp95, ICBP90, Nuclear protein 95, RING finger protein 106, RNF106, Transcription factor ICBP90, UHRF1

Uniprot	Q96T88
Gene Id	29128
Research Area	Epigenetics, Cancer, Metabolism
Weight	91kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IF

Description

ELISA ; WB ; IF

Dilution

WB	1:500-1:5000
IP	1:500-1:5000
IF	1:10-1:100

Tested Application

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:20 - 1:50

Manual	FNab09245.pdf

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10809234	FNab09245	100ug	$280		Add to Cart

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