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Home / Primary Antibodies / Polyclonal Antibodies

ubiquitin antibody

SKU : BHA10809187

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Mfr.No.	FNab09197
Alternative Names	FLJ25987 ; PolyubiquitinB ; UBB ; ubiquitin ; ubiquitinB
Background	Ubiquitin B(UBB) is a member of ubiquitin family, one of the most conserved proteins known. Ubiquitin B is required for ATP-dependent, non-lysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover. Ubiquitin B is covalently bound to proteins to be degraded, and presumably labels these proteins for degradation. Ubiquitin also binds to histone H2A in actively transcribed regions but does not cause histone H2A degradation, suggesting that ubiquitin is also involved in regulation of gene expression.When polyubiquitin is free(unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Aberrant form of this protein has been noticed in patients with Alzheimer's and Down syndrome. Interestingly ubiquitin also becomes covalently bonded to many types of pathological inclusions which appear to be resistant to normal degradation.
Categories	Primary Antibodies
Cellular Localization	Cytoplasm, Nucleus
Clonality	polyclonal
Description	Ubiquitin B (UBB) is a member of ubiquitin family, one of the most conserved proteins known. Ubiquitin B is required for ATP-dependent, non-lysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover. Ubiquitin B is covalently bound to proteins to be degraded, and presumably labels these proteins for degradation. Ubiquitin also binds to histone H2A in actively transcribed regions but does not cause histone H2A degradation, suggesting that ubiquitin is also involved in regulation of gene expression.When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Aberrant form of this protein has been noticed in patients with Alzheimer's and Down syndrome. Interestingly ubiquitin also becomes covalently bonded to many types of pathological inclusions which appear to be resistant to normal degradation.
Host	Rabbit
Immunogen	ubiquitin B
Isotype	IgG
Molecular Weight	8 kDa, 15 kDa,24 kDa, 34 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Subcellular Location	Cytoplasm, Nucleus
Synonyms	FLJ25987, Polyubiquitin B, UBB, ubiquitin, ubiquitin B

Uniprot	P0CG47
Gene Id	7314
Research Area	Immunology, Metabolism
Weight	26kDa,Observed 8kDa,15kDa，24kDa,34kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, IHC, IP, WB

Description

ELISA ; IHC ; IP ; WB

Dilution

WB	1:200-1:2000
IP	1:200-1:1000
IHC	1:50-1:200

Tested Application

WB: 1:200-1:2000; IP: 1:200-1:1000; IHC: 1:50-1:200

Manual	FNab09197.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10809187	FNab09197	100ug	$260		Add to Cart

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