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Home / Primary Antibodies / Polyclonal Antibodies

Ubiquilin 1 antibody

SKU : BHA10809186

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Mfr.No.	FNab09196
Alternative Names	DA41 ; DSK2 ; FLJ90054 ; hPLIC1 ; PLIC1 ; PLIC1 ; ubiquilin1 ; UBQLN1 ; XDRP1
Background	UBQLN1, also known as DSK2 or Ubiquilin 1, is an ubiquitin-like proteinis contains a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation.Ubiquilin has also been shown to modulate accumulation of presenilin proteins, and is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene. Higher levels of ubiquilin-1 in the brain decreased malformation of the APP molecule which plays a key role in triggering Alzheimers disease.Conversely, lower levels of ubiquilin-1 in the brain were associated with increased malformation of APP (PMID: 21852239). This antibody detects 70kD band of UBQLN1.
Categories	Primary Antibodies
Cellular Localization	Cytoplasm, Cytoplasmic Vesicle, endoplasmic reticulum, Membrane, Nucleus, Proteasome
Clonality	polyclonal
Description	UBQLN1, also known as DSK2 or Ubiquilin 1, is an ubiquitin-like proteinis contains a?N-terminal?ubiquitin-like?domain?and a C-terminal ubiquitin-associated domain.?They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation.Ubiquilin has also been shown to modulate accumulation of presenilin proteins, and is found in lesions associated with?Alzheimer's?and?Parkinson's?disease. Two transcript variants encoding different isoforms have been found for this gene. Higher levels of ubiquilin-1 in the brain decreased malformation of the APP molecule which plays a key role in triggering Alzheimers disease.Conversely, lower levels of ubiquilin-1 in the brain were associated with increased malformation of APP?(PMID: 21852239). This antibody detects 70kD band of UBQLN1.
Host	Rabbit
Immunogen	ubiquilin 1
Isotype	IgG
Molecular Weight	71 kDa
Reactivity	Human, Rat
Regulatory	RUO
Subcellular Location	Cell membrane, Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Membrane, Nucleus, Proteasome
Synonyms	DA41, DSK2, FLJ90054, hPLIC 1, PLIC 1, PLIC1, ubiquilin 1, UBQLN1, XDRP1

Uniprot	Q9UMX0
Research Area	Metabolism
Weight	70kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, IHC, WB, IF

Description

ELISA ; IHC ; WB ; IF

Dilution

WB	1:200-1:1000
IF	1:10-1:100
IHC	1:20-1:200

Tested Application

WB: 1:200-1:1000; IF: 1:10-1:100; IHC: 1:20-1:200

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SKU	Supplier No.	Size	Your price	Quantity
BHA10809186	FNab09196	100ug	$240		Add to Cart

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