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Home / Primary Antibodies / Polyclonal Antibodies

UBE2K antibody

SKU : BHA10809170

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Mfr.No.	FNab09178
Alternative Names	DKFZp564C1216 ; DKFZp686J24237 ; E2-25K ; HIP2 ; HIP2 ; HYPG ; LIG ; UBE2K ; Ubiquitincarrierprotein ; Ubiquitinproteinligase
Background	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation(ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1.
Categories	Primary Antibodies
Cellular Localization	Cytoplasm
Clonality	polyclonal
Description	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein- dependent degradation of RB1.
Host	Rabbit
Immunogen	ubiquitin-conjugating enzyme E2K
Isotype	IgG
Molecular Weight	25 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Subcellular Location	Cytoplasm
Synonyms	DKFZp564C1216, DKFZp686J24237, E2-25K, HIP 2, HIP2, HYPG, LIG, UBE2K, Ubiquitin carrier protein, Ubiquitin protein ligase

Uniprot	P61086
Gene Id	3093
Research Area	Epigenetics, Immunology, Metabolism, Neuroscience
Weight	22kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC

Dilution

WB	1:500-1:5000
IHC	1:20-1:200

Tested Application

WB: 1:500-1:2000; IHC: 1:20-1:200

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SKU	Supplier No.	Size	Your price	Quantity
BHA10809170	FNab09178	100ug	$260		Add to Cart

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