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Home / Primary Antibodies / Polyclonal Antibodies

UBE2C antibody

SKU : BHA10809157

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Mfr.No.	FNab09165
Alternative Names	DJ447F3.2 ; UBCH10 ; UBE2C ; UbiquitincarrierproteinC ; UbiquitinproteinligaseC
Background	The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is required for the destruction of mitotic cyclins and for cell cycle progression, and may be involved in cancer progression. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been defined on chromosomes 4, 14, 15, 18, and 19.
Categories	Primary Antibodies
Cellular Localization	Cytoplasm, Uclear
Clonality	polyclonal
Description	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit.
Host	Rabbit
Immunogen	ubiquitin-conjugating enzyme E2C
Isotype	IgG
Molecular Weight	17 kDa
Reactivity	Human
Regulatory	RUO
Subcellular Location	Cytoplasm,nuclear
Synonyms	DJ447F3.2, UBCH10, UBE2C, Ubiquitin carrier protein C, Ubiquitin protein ligase C

Uniprot	O00762
Gene Id	11065
Research Area	Epigenetics, Metabolism
Weight	20kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IHC, IP

Description

ELISA ; WB ; IHC ; IP

Dilution

WB	1:200-1:2000
IHC	1:20-1:200
IP	1:10-1:100

Tested Application

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:100; IP: 1:20 - 1:50

Manual	FNab09165.pdf

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10809157	FNab09165	100ug	$260		Add to Cart

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