This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor.
Categories
Primary Antibodies
Cellular Localization
Cytoplasm, Nucleus
Clonality
polyclonal
Description
UBASH3B, also named STS1 or TULA-2, is a protein that contains a ubiquitin-associated domain at the N-terminus, a SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. TULA-2 is supposed to form homodimer and interact with ubiquitin and mono-ubiquitinated proteins. TULA-2 functions to promote accumulation of activated target receptors, such as T-cell receptors and EGFR on the cell surface.
Host
Rabbit
Immunogen
ubiquitin associated and SH3 domain containing, B
Isotype
IgG
Molecular Weight
73 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Subcellular Location
Cytoplasm, Nucleus
Synonyms
Cbl interacting protein p70, KIAA1959, p70, STS 1, STS1, UBASH3B
Uniprot
Q8TF42
Gene Id
84959
Research Area
Metabolism
Weight
70kDa
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)