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Home / Primary Antibodies / Polyclonal Antibodies

TXNIP antibody

SKU : BHA10809121

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Mfr.No.	FNab09129
Alternative Names	EST01027 ; HHCPA78 ; THIF ; Thioredoxinbindingprotein2 ; TXNIP ; VDUP1
Background	May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1(mTORC1).
Categories	Primary Antibodies
Cellular Localization	Cytoplasm
Clonality	polyclonal
Description	May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over- expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).
Host	Rabbit
Immunogen	thioredoxin interacting protein
Isotype	IgG
Molecular Weight	50 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Subcellular Location	Cytoplasm
Synonyms	EST01027, HHCPA78, THIF, Thioredoxin binding protein 2, TXNIP, VDUP1

Uniprot	Q9H3M7
Gene Id	10628
Research Area	Metabolism
Weight	50kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, IHC, WB, IF

Description

ELISA ; IHC ; WB ; IF

Dilution

WB	1:200-1:2000
IP	1:200-1:2000
IHC	1:50-1:500
IF	1:10-1:100

Tested Application

WB: 1:200-1:2000; IP: 1:200-1:2000; IHC: 1:50-1:500; IF: 1:10-1:100

Manual	FNab09129.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10809121	FNab09129	100ug	$260		Add to Cart

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