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Home / Primary Antibodies / Polyclonal Antibodies

TSHR antibody

SKU : BHA10809037

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Mfr.No.	FNab09045
Alternative Names	CHNG1 ; hTSHRI ; LGR3 ; Thyrotropinreceptor ; TSHR ; TSHR
Background	The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. The gene of TSHR maps to chromosome 14q31.1, and encodes a 764-amino acid protein with a predicted unmodified molecular weight of 86.8 kDa. The apparent molecular weight of glycosylated form is 95-120 kDa. Studies reveal that TSHR is composed of two subunits, A and B, which are produced by cleavage of single-chain TSHR on the cell surface and subsequently connected by disulfide bonds. This rabbit polyclonal antibody can detect glycosylated subunit A with an experimentally determined molecular weight of 62-70 kDa under reducing condition. (PMID: 20578897, 17158770, 12593718)
Categories	Primary Antibodies
Clonality	polyclonal
Description	Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5).
Host	Rabbit
Immunogen	thyroid stimulating hormone receptor
Isotype	IgG
Molecular Weight	62-100 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	CHNG1, hTSHR I, LGR3, Thyrotropin receptor, TSH R, TSHR

Uniprot	P16473
Gene Id	7253
Research Area	Cancer, Signal Transduction
Weight	87kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB

Description

ELISA ; WB

Dilution

WB	1:500-1:5000

Tested Application

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:20- 1:50

Manual	FNab09045.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10809037	FNab09045	100ug	$260		Add to Cart

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