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Home / Primary Antibodies / Polyclonal Antibodies

TRX antibody

SKU : BHA10809025

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Mfr.No.	FNab09033
Alternative Names	ADF ; ATLderivedfactor ; DKFZp686B1993 ; SASP ; Thioredoxin ; TRDX ; TRX ; TRX1 ; TXN
Background	The protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. This protein is found in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene.
Categories	Primary Antibodies
Cellular Localization	Cytoplasm, Nucleus, Secreted
Clonality	polyclonal
Description	TXN, TRDX, TRX, TRX1, ADF and SASP, belongs to the thioredoxin family. It participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. TXN plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. TXN induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.
Host	Rabbit
Immunogen	thioredoxin
Isotype	IgG
Molecular Weight	Refer to Figures
Reactivity	Human, Mouse
Regulatory	RUO
Subcellular Location	Cytoplasm, Nucleus, Secreted
Synonyms	ADF, ATL derived factor, DKFZp686B1993, SASP, Thioredoxin, TRDX, TRX, TRX1, TXN

Uniprot	P10599
Gene Id	7295
Research Area	Metabolism, Cancer
Weight	12kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IHC, IF, FC

Description

ELISA ; WB ; IHC ; IF ; FC

Dilution

WB	1:1000-1:10000
IP	1:200-1:1000
IHC	1:100-1:400
IF	1:20-1:200

Tested Application

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IP : 1:20 - 1:50

Manual	FNab09033.pdf

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10809025	FNab09033	100ug	$260		Add to Cart

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