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Home / Primary Antibodies / Polyclonal Antibodies

TRPM5 antibody

SKU : BHA10809013

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Mfr.No.	FNab09021
Alternative Names	LTrpC5 ; LTRPC5 ; MTR1 ; TRPM5
Background	Voltage-modulated Ca(2+)-activated, monovalent cation channel(VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent-specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+). Also activated by a fast intracellular Ca(2+) increase in response to inositol 1,4,5-triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. Heat activation is due to a shift of the voltage-dependent activation curve to negative potentials. Activated by arachidonic acid in vitro. May be involved in perception of bitter, sweet and umami tastes. May also be involved in sensing semiochemicals.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent- specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+). Also activated by a fast intracellular Ca(2+) increase in response to inositol 1,4,5- triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. Heat activation is due to a shift of the voltage- dependent activation curve to negative potentials. Activated by arachidonic acid in vitro. May be involved in perception of bitter, sweet and umami tastes. May also be involved in sensing semiochemicals.
Host	Rabbit
Immunogen	transient receptor potential cation channel, subfamily M, member 5
Isotype	IgG
Molecular Weight	98 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	LTrpC 5, LTRPC5, MTR1, TRPM5

Uniprot	Q9NZQ8
Gene Id	29850
Research Area	Signal Transduction
Weight	98kDa,Observed 98kDa,80kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IF

Description

ELISA ; WB ; IF

Dilution

WB	1:500-1:5000
IP	1:200-1:1000

Tested Application

WB: 1:500-1:5000; IP: 1:200-1:1000; IF: N/A

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SKU	Supplier No.	Size	Your price	Quantity
BHA10809013	FNab09021	100ug	$260		Add to Cart

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