E3 ubiquitin-protein ligase. Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling.
Categories
Primary Antibodies
Clonality
polyclonal
Description
E3 ubiquitin-protein ligase. Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling.
Host
Rabbit
Immunogen
tripartite motif-containing 38
Isotype
IgG
Molecular Weight
53 kDa
Reactivity
Human
Regulatory
RUO
Synonyms
RING finger protein 15, RNF15, RORET, TRIM38, tripartite motif containing 38, Zinc finger protein RoRet
Uniprot
O00635
Gene Id
10475
Research Area
Signal Transduction, Metabolism
Weight
53kDa
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)