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Home / Primary Antibodies / Polyclonal Antibodies

TRIM33 antibody

SKU : BHA10808973

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Mfr.No.	FNab08981
Alternative Names	Ectoderminhomolog ; FLJ32925 ; KIAA1113 ; ProteinRfg7 ; PTC7 ; RETfusedgene7protein ; RFG7 ; TF1G ; TIF1gamma ; TIF1G ; TIF1GAMMA
Background	Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor(By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade(Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).
Categories	Primary Antibodies
Cellular Localization	Nucleus
Clonality	polyclonal
Description	Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF- beta/BMP signaling cascade).
Host	Rabbit
Immunogen	tripartite motif-containing 33
Isotype	IgG
Molecular Weight	140-150 kDa
Reactivity	Human
Regulatory	RUO
Subcellular Location	Nucleus
Synonyms	Ectodermin homolog, FLJ32925, KIAA1113, Protein Rfg7, PTC7, RET fused gene 7 protein, RFG7, TF1G, TIF1 gamma, TIF1G, TIF1GAMMA, TIFGAMMA, TRIM33, tripartite motif containing 33

Uniprot	Q9UPN9
Gene Id	51592
Research Area	Metabolism
Weight	120kDa,Observed 150kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB

Description

ELISA ; WB

Dilution

WB	1:200-1:2000

Tested Application

WB: 1:200-1:2000

Manual	FNab08981.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10808973	FNab08981	100ug	$280		Add to Cart

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