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Home / Primary Antibodies / Polyclonal Antibodies

TRIM27 antibody

SKU : BHA10808969

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Mfr.No.	FNab08977
Alternative Names	Retfingerprotein ; RFP ; RINGfingerprotein76 ; RNF76 ; TRIM27 ; tripartitemotifcontaining27 ; ZincfingerproteinRFP
Background	E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASH1, leading to promote endosomal F-actin assembly(PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA.
Categories	Primary Antibodies
Clonality	polyclonal
Description	E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T- cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASH1, leading to promote endosomal F-actin assembly (PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double- stranded DNA.
Host	Rabbit
Immunogen	tripartite motif-containing 27
Isotype	IgG
Molecular Weight	58 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	Ret finger protein, RFP, RING finger protein 76, RNF76, TRIM27, tripartite motif containing 27, Zinc finger protein RFP

Uniprot	P14373
Gene Id	5987
Research Area	Developmental biology, Cancer, Metabolism
Weight	58kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IHC, IP

Description

ELISA ; WB ; IHC ; IP

Dilution

WB	1:500-1:2000
IP	1:500-1:5000
IHC	1:20-1:200
IF	1:20-1:200

Tested Application

WB: 1:500-1:2000; IP: 1:500-1:5000; IHC: 1:20-1:200; IF: 1:20-1:200

Manual	FNab08977.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10808969	FNab08977	100ug	$260		Add to Cart

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